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| The immune adjustment mechanism of anti-tumor efficacy of SGTR on H22 tumor bearing mice |
| Hits 2165 Download times 2213 Received:April 26, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.04.23 |
| Key Words
SGTR;H22 cells;immune regulation |
| Author Name | Affiliation | | YU Xiao-hong | Department of Microbiology and Immunology, Heilongjiang University of TCM, Harbin 150040, China | | SONG Na | Department of Microbiology and Immunology, Heilongjiang University of TCM, Harbin 150040, China | | HU Yan-wen | Maternal and Child Health Hospital of Tianjin Tanggu District, Tianjin 319000, China |
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| Abstract
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| [Objective] Study the adjustment function of SGTR on the immune system of tumor-bearing mice and investigate the immunological mechanism of the inhibition function of SGTR on tumor’s growth.[Methods] H22 tumor bearing mice were as the research object.We measured the levels of IL-2 and IL-4 in serum with ELISA method,and the influence of SGTR on CD4+、CD8+ T cell with FACS method.[Results] SGTR can improve the expression of IL-2 cytokines in H22 tumor bearing mice’s serum,lower the level of IL-4,increase the expression of CD4+ T cells,and reduce the expression of CD8+ T cells in H22 tumor bearing mice.[Conclusion] SGTR could play a role of anti-tumor activity by regulating the body’s abnormal immune function in tumor-bearing state. |
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