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| Experiment research on PESV for inhibiting activation of leucemia stem cell in the niche |
| Hits 1272 Download times 1774 Received:April 10, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.04.24 |
| Key Words
PESV;LSC;niche;activating effect |
| Author Name | Affiliation | | YANG Xiang-dong | Department of Hematology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | YANG Wen-hua | Department of Hematology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | SHI Zhe-xin | Department of Hematology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | 刘宝山 | Department of Hematology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | 高宏 | Department of Hematology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | 张蕾 | Department of Hematology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | 陈艳鑫 | Department of Hematology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of PESV(peptide extract from scorpion venom) for inhibiting the activation of leucemia stem cells(LSC) in the niche.[Methods] LSC were isolated from patients with AML/ALL and stored in the Trans well.Then they were divided into four groups: high-dose group,middle-dose group,low-dose group and the positive control group.After cultured with different concentrations of PESV,the transport ratios of LSC in various concentration groups were computed at different time.[Results] The transport ratios cultured with different concentrations of PESV were(25.01±6.83)%,(36.85±3.83)%,(50.73±7.15)%,and there was a significant difference compared with that of the positive control group(49.10±6.12)%(P<0.05).The transport ratio in the high-dose group is more than that of the middle and lose-dose groups.[Conclusion] All different concentrations of PESV have the inhibiting effects against the activation of LSC with a inhibiting intensity depending on the concentrations of PESV. |
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