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| Study on the antidepressant effect of total flavonoids from Semen Ziziphi Spinosae |
| Hits 1909 Download times 2279 Received:March 30, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.04.26 |
| Key Words
Semen Ziziphi Spinosae;total flavonoids;antidepressant effect;behavioral despair |
| Author Name | Affiliation | | ZHAO Qi-duo | School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | SHU Le-xin | School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | WANG Ying | School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 牟佳佳 | School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 宋志国 | 吉林熬东集团大连药业股份有限公司, 大连, 116043 | | 李金梅 | 吉林熬东集团大连药业股份有限公司, 大连, 116043 |
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| Abstract
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| [Objective] To observe the antidepressant effect of total flavonoids from Semen Ziziphi Spinosae in mice.[Methods] To investigate the antidepressant activity of total Flavonoids from Semen Ziziphi Spinosae by the forced swimming test and the tail suspension test,with behavioral despair mice in the immobility time as an indicator.[Results] Different dose groups of total flavonoids from Semen Ziziphi Spinosae could significantly reduce the immobility time of mice during the forced swimming test and the tail Suspension test,compared with that of the control group(P<0.05);compared with that of the positive group(P<0.05).[Conclusion] The total flavonoids from Semen Ziziphi Spinosae possess had significant antidepressant effects. |
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