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| Determination of preparation and dissolution with Naokangtongtai dispersible tablet |
| Hits 1839 Download times 1741 Received:June 17, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.05.27 |
| Key Words
Naokangtongtai dispersible tablets;preparation technology;dissolution |
| Author Name | Affiliation | | WANG Wei | Tianjin University of TCM, Tianjin 300193, China | | LI Hong-qi | State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin 300193, China | | ZOU Jun-zhong | Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China | | 任晓文 | TIPR Pharmaceutical Responsible Co.,Ltd, Tianjin 300193, China |
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| Abstract
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| [Objective] To prepare Naokangtongtai dispersible tablets and establish the dissolution method.To compare with the dissolution of other common products.[Methods] The formulation of the tablets was optimized through the indices: slope of repose,hardness,disintegration time and corpuscular liquidity.Dissolution was determined by the solvent according to the method in Chinese Pharmacopoeia(2010,Appendix Ⅱ) with 900 mL water as the solvent at a rotation speed of 100 r/min.And the detection wavelength was 270 nm.[Results] The proportion of each adjuvant in the optimal formulation consisted of 20% microcrystalline cellulose and 24% brushite as a filler,and 10% crospovidone mixed with 2% silicon dioxide as disintegrating agent,1% magnesium stearate as lubricants.The dispersible tablets could disintegrate completely within 3 minutes and its dissolution rate could reach beyond 75% in 30 min.[Conclusion] The preparative method of Naokangtongtai dispersible tablets by wet granulation is simple.The method is accurate and suitable for the dissolution determination of Naokangtongtai dispersible tables. |
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