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| Effect of Xiaokeshen prescription on blood hemorheology,urinary albumin excretion rate and endothelin 1 in patients with early diabetic nephropathy |
| Hits 1823 Download times 2080 Received:May 27, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.06.06 |
| Key Words
Xiaokeshen prescription;diabetic nephropathy;hemorheology;proteinuria;endothelin 1 |
| Author Name | Affiliation | | MA Li | The Affiliated Hospital of TCM Institute of Tianjin, Tianjin 300120, China | | CHE Shu-qiang | The Affiliated Hospital of TCM Institute of Tianjin, Tianjin 300120, China |
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| Abstract
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| [Objective] To observe the effect of Xiaokeshen prescription on blood hemorheology,urinary albumin excretion rate and endothelin 1 in patients with early diabetic nephropathy.[Methods] Seventy-four patients were randomly divided into two groups: treatment group(37cases) and control group(37cases).The patients of two groups were received the same basic treatment including diet control and hypoglycemic therapy.The treatment group was given with Xiaokeshen prescription simultaneously and the control group was given with Cozaar.After treatment for four months and a half the hemorheology,urinary albumin excretion rate and endothelin 1 were detected.[Results] After treatment,indexes of hemorheology in treatment group were obviously decreased(P<0.05) and better than that in the control group(P<0.05).There was a statistical significance in urinary albumin excretion rate and endothelin 1 after treatment in both groups(P<0.05).But there was no statistical significance between two groups(P>0.05).[Conclusion] Xiaokeshen prescription can improve hemorheology,decrease endothelin 1,and reduce the excluding content of plasma urinary albumin in patients with DN.Xiaokeshen prescription has significant curative effect on patient with DN. |
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