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| Influence of stress stimulation on serum epinephrine and norepinephrine in rats with experimental type 2 diabetes mellitus tendency |
| Hits 2270 Download times 1901 Received:July 11, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.06.22 |
| Key Words
emotion stimulation;diabetes mellitus;epinephrine;norepinephrine |
| Author Name | Affiliation | | LIU Yan-min | The PLA 272 Hospital, Tianjin 300020, China | | LI Jie | The Psychological Department of Intermongolia Normal University, Huhehaote 010000, China | | LI Qing-he | Tianjin University of TCM, Tianjin 300193, China | | 韩娟 | Tianjin University of TCM, Tianjin 300193, China | | 苑朝升 | The PLA 272 Hospital, Tianjin 300020, China | | 李慧吉 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the mechanisms of action of emotion stimulation in the onset of type 2 DM(Qi-ji disorder syndrome),and the effect of Xinshen NO.5,a compound prescription having effect of regulating Qi,lowering the abnormal ascending Qi and dispersing accumulation of pathogen from the pathogenesis with many factors.[Methods] The type 2 DM disease was induced by abdominal injecting a small dosage of STZ combined with psychophysiological stimulation(rotation,restraint and crowding) simultaneously.The animals were divided into five groups: normal group,stress group,STZ group,stress+STZ group and treatment group by Chinese herbs.Each group was checked for the level of serum epinephrine and norepinephrine.At the same time we observed the regulatory action of compound formula Xinshen NO.5.[Results] Emotional stimulation could increase the level of serum epinephrine and norepinephrine in STZ rats.The rats in STZ plus stimulation group had the highest content(P<0.01).Chinese herb could lower the content.[Conclusion] The increase of serum epinephrine and norepinephrine level induced by chronic emotional stimulation is one of the pathogenesis in the tendency of type 2 DM.The regulatory action of compound formula Xinshen NO.5.is apparent. |
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