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| Effect of intravenous injection of extracted solution of Semen Coicis for survival rate,survival time and brain edema in rats with cerebral ischemia |
| Hits 2199 Download times 1970 Received:September 06, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.06.23 |
| Key Words
Semen Coicis(Yiyiren);cerebral ischemia;brain edema;survival time |
| Author Name | Affiliation | | GAO Liang | Tianjin University of TCM, Tianjin 300193, China | | DU Yuan-hao | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | LI Zhong-zheng | Tianjin University of TCM, Tianjin 300193, China | | 田力欣 | Tianjin University of TCM, Tianjin 300193, China | | 郭义 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the influences of Semen Coicis(Yiyiren) on the survival rate,survival time and brain edema in rats with experimental cerebral ischemia.[Methods] Healthy male SD rats were selected,and then were randomly divided into the normal group,sham operation group,model group and Semen Coicis(Yiyiren) group.Middle cerebral artery occlusion(MCAO) models were established according to Longa method.The brains were taken at 48 hours after establishing the model,and the brain water content and brain coefficient were measured.The survival rate of rats in each group and the survival time of the dead rats were calculated.[Results] After intravenous injection of Semen Coicis(Yiyiren) of extracted solution,the survival time of rats that died within 48 hours after cerebral ischemia was prolonged,the brain water content and coefficient value weren reduced.[Conclusion] Semen Coicis(Yiyiren) has the tendency of promoting the survival rate of rats after cerebral ischemia in 48 hours,has certain effect of prolonging the survival time of rats that died within 48 hours after cerebral ischemia,and has certain improving function on ischemic brain edema. |
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