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| Long-term toxicity study of Ruanganhuaxian pills in rats |
| Hits 1717 Download times 1857 Received:August 16, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2011.06.27 |
| Key Words
Ruanganhuaxian pills;long-term toxicity;SD rats |
| Author Name | Affiliation | | HUANG Yan-xia | The Tianjin Hospital for Infectious Diseases, Tianjin 300192, China |
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| Abstract
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| [Objective] To observe the long-term toxicity in rats after oral administration of Ruanganhuaxian pills.[Methods] Ruanganhuaxian pills were orally administered to rats at the dosage of 3.0,1.5 g/(kg·d),continuously for 26 weeks.At the end of the administration and four weeks after it,parameters of body weight,hematology,hematological biochemics,organ/body weight ratio and pathohistology were detected.[Results] Rats from all dosage groups developed normally.No treatment-related abnormal change was observed and no toxic pathological change of pathomorphology occurred in the main organs of the rats.[Conclusion] Ruanganhuaxian pills has low long-term toxicity with the organs,toxicity target organ is not found,and it can be safely used in clinic. |
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