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| Effects of Chinese medicine of activating blood circulation and dissolving stasis,eliminating mass and killing embryo on ER,PR expression in the fallopian mucosa and Bcl-2 expression in decidua |
| Hits 1772 Download times 2109 Received:October 20, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2012.01.11 |
| Key Words
Chinese medicine of activating blood circulation and dissolving stasis,eliminating mass and killing embryo;fallopian pregnancy;fallopian mucosa;deciduas;ER;PR |
| Author Name | Affiliation | | SUN Jia-qi | The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China | | YUAN Shuo | The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China | | DENG Gao-pi | The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China |
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| Abstract
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| [Objective] To discuss the mechanism of the Chinese medicine of activating blood circulation and dissolving stasis,eliminating mass and killing embryo on the fallopian pregnancy through the ER,PR expression on the fallopian pregnancy mucous membrane and Bcl-2 expression on the decidua.[Methods] According to the scoring model about influence factors in pathologic condition of fallopian pregnancy and the differentiation scheme of treatment for fallopian pregnancy(formulated by specialist group of fallopian pregnancy,state administration of traditional Chinese medicine).30 cases of fallopian tissues removed by surgery in patients with obstruction of meridian by embryo and having 8 of evaluating scores(observation group 15 cases,control group 15 cases) were collected and their expressions of ER and PR and the BcL-2 in decidua were determined with immunohistochemistry.In the observation group 15 cases of pregnant fallopian tissue removed by surgery were used for determining these parameters 3 days after oral taking traditional Chinese medicine;in control group 15 cases of the normal pregnant fallopian tissue without any treatment were used.[Results] The Chinese medicine could reduce the expression of Bcl-2 in the decidua(P<0.05),increase the PR expression of fallopian tube(P<0.05),but had no obvious impact on ER expression of fallopian tube(P>0.05).[Conclusion] Inducing apoptosis and reducing the accommodation of the fallopian mucosa may be the two effects of the Chinese medicine of activating blood circulation and dissolving stasis,eliminating mass and killing embryo. |
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