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| Establishmentement of animal model with duodenum-stomach- esophageal reflux |
| Hits 1436 Download times 1556 Received:October 18, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2012.01.23 |
| Key Words
esophagitis;duodenum-stomach-esophageal reflux;model;rat |
| Author Name | Affiliation | | LIANG Xin-sheng | Zouping County TCM Hospital of Shandong, Zouping 256200, China | | SONG Chen-guang | Zouping County TCM Hospital of Shandong, Zouping 256200, China | | YUAN Hong-xia | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To improve the operation fashion of interrupted suture of “four walls and four stitches” and improve the establishment of animal models of deodenum-stomach-esophageal reflux. [Methods] The blank group(A) accepted no any special treatment while both the control(B) and the model(C) group received “four walls and four stitches” interrupted suture. Materials were obtained 5 days after modeling in group B while 10 days after that in C group. [Results] The survival rate of model group(83.4%) was significantly higher than that of control group(64.8%) (P<0.05). Both macroscopic characteristics and pathological changes of lower esophagus mucosa of rats in model group was significantly different from that of rats in control group (P<0.05). [Conclusion] The modified operating fashion in modeling can delay the survival rate and successfully induce reflex esophagitis and Barrett's esophagus. |
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