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| Establishment of pharmacological evaluation system on the character and taste in Fructus Evodiae |
| Hits 1702 Download times 1450 Received:October 22, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2012.01.25 |
| Key Words
Evodia;taste pharmacology;cluster analysis;statistics |
| Author Name | Affiliation | | YANG Zhi-xin | Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Heilongjiang key Laboratory of TCM Pharmacodynamic Material Bases, Haerbin 150040, China | | MENG Yong-hai | Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Heilongjiang key Laboratory of TCM Pharmacodynamic Material Bases, Haerbin 150040, China | | WANG Qiu-hong | Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Heilongjiang key Laboratory of TCM Pharmacodynamic Material Bases, Haerbin 150040, China | | YANG Bing-you | Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Heilongjiang key Laboratory of TCM Pharmacodynamic Material Bases, Haerbin 150040, China | | KUANG Hai-xue | Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Heilongjiang key Laboratory of TCM Pharmacodynamic Material Bases, Haerbin 150040, China |
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| Abstract
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| [Objective] To construct the taste pharmacology evaluation system with communication of Chinese herb medicine theory and modern medical theory by taking Evodia as research object. [Methods] Through textual research and modern literature study, using the traditional Chinese way of thinking and deductive method, and based on the establishment of modern pharmacological targets literature database, using logistic by means of regression analysis and cluster analysis in the methods of modern statistics the Evodia taste-efficacy-pharmacological index correlation was established, and the Evodiae taste pharmacology evaluation system was then constructed objectively. [Results] Through analysis based on the literature, the index of Evodia taste and pharmacology were: pungent taste was associated with analgesic and anti-inflammatory effect, bitterness taste was associated with effect of preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer. Analysis based on literature database, the relationship of traditional Chinese medicine “five flavor” and pharmacological index was: analgesic and anti-inflammatory were associated with pungent taste; preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer were associated with bitterness taste. The results of cluster analysis also showed that the analgesic and anti-inflammatory were classified in one category, preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer were in one category. [Conclusion] The results of herbal medicine research and modern literature research are the same, all of them is pungent taste and is associated with analgesic and anti-inflammatory, bitterness taste is associated with preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer. The Evodia rutaecarpa taste pharmacology evaluation system was thereby built scientifically. |
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