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| Effect of EPCs pretreated with salvianolic acid B in microenvironment of myocardial muscle after transplantation of bone mesenchymal stem cells in AMI rats |
| Hits 1849 Download times 1840 Received:December 05, 2011 |
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| DOI
10.11656/j.issn.1672-1519.2012.02.05 |
| Key Words
Salvianolic acid B(SalB);acute myocardialin infarction(AMI);endothelial progenitor cells(EPCs);bone mesenchymal stem cells(BMSCs);cell transplantation |
| Author Name | Affiliation | | HUA Sheng-yu | Tianjin University of TCM, Tingjing 300193, China | | ZHAO Gui-feng | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | LI Qing-wen | Tianjin College of Physical Education, Tianjin 300381, China | | FAN Ying-chang | Tianjin University of TCM, Tingjing 300193, China |
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| Abstract
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| [Objective] To investigate the effect of salvianolic acid B preconditioned endothelial progenitor cells(EPCs) combined with implantation of bone mesenchymal stem cells(BMSCs) on the gene expression in rats with acute myocardial infarction(AMI).[Methods] Forty-two AMI rats were divided randomly into sham operation model,BMSCs and EPCs combined with BMSCs transplantation group,and EPCs preconditioned with salvianolic acid B combined with transplantation of BMSCs were injected into five points of heart ischemia area.[Result] After 4 weeks,among each combined cell transplantation group,in 2∶1,4∶1 and 8∶1 group in the area of Brdu concentrated expression positive α-MHC expression at different degree could be found.Except that the sham operation group had less expression,all the area with myocardial infarction underwent coronary artery ligation in rats the type I collagen expression increased.[Conclusion] Salvianolic acid B-preconditioned EPCs with transplanted BMSCs under the microenvironment of myocardial muscle can be differentiated into myocardial cells.They can prevent or improve the occurrence of ventricular remodeling. |
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