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| Effect of Xi Feng capsule on hippocampal lesion in rats with epilepsy induced by lithium-pilocarpine |
| Hits 1749 Download times 1685 Received:May 17, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.04.05 |
| Key Words
epilepsy;Xi Feng capsule;hippocampus;lithium-pilocarpine;spontaneous recurrent seizures;mossy fiber sprouting |
| Author Name | Affiliation | | LI Xin-min | Pediatric Department, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | REN Yan-yan | Pediatric Department, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | CHEN Hui | Pediatric Department, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | LU Yan-li | Pediatric Department, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the effect of Xi Feng capsule on hippocampal lesion in rats with epilepsy induced by Lithium-pilocarpine. [Methods] Lithium-pilocarpine was used to duplicate the epilepsy in rats. Then the spontaneous recurrent seizures(SRS) of rats was observed and recorded by the vedio control system. The conventional histopathological method and transmission electron microscope were utilized to observe the morphological changes in hippocampus. Timm histochemical technique was adopted to study mossy fiber sprouting(MFS). [Results] 1)The recurrent time of SRP in treatment group was much less than model group (P < 0.01). 2)Conventional histopathological method and transmission electron microscope found that, in all therapy groups, the damage of neuron in hippocampus was ameliorated in Xi Feng high-dose + Carbamazepine(CBZ)1/2 dose group. 3)The result of Timm stain method suggested that the hippocampal CA3 subfield in Xi Feng high-dose + CBZ 1/2 dose group was less than that of Xi Feng single group. This effect of Xi Feng capsule could be increased as its dose increased. [Conclusion] Xi Feng capsule only and combined with CBZ can control the SRS of rat with epilepsy induced by lithium-pilocarpine, and protect hippocampal neurons from more serious lesson and inhibit mossy hippocampal MFS. |
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