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Experimental effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in mice
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DOI   10.11656/j.issn.1672-1519.2012.04.22
Key Words   Drynaria fortunei;external application;cyclophosphamide;alopecia areata
Author NameAffiliation
HUANG Yun-ying Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM, Tianjin 300193,China 
ZHANG De-qin Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM, Tianjin 300193,China 
SHEN Li Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM, Tianjin 300193,China 
WANG Xue-ni Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM, Tianjin 300193,China 
DU Juan Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM, Tianjin 300193,China 
WANG Yuan-yuan Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM, Tianjin 300193,China 
Abstract
    [Objective] To investigate the effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in C57BL/6 mice. [Methods] Severe alopecia was induced by cyclophosphamide in these mice. The hair growth and histological changes were observed in the back skin of them. The levels of ICAM-1 and ELAM-1 in the serum were determined by ELISA. [Results] The levels of ICAM-1 and ELAM-1 in herbal group were lower than that in the control group. The nutrition of hair follicles was also improved. [Conclusions] The extract from Drynaria fortunei has a promoting effect on the hair growth by its external application.

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