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| Effect of Xihuang pills on protein expressions of MMP-2 and MMP-9 in human colorectal carcinoma LoVo cell |
| Hits 1735 Download times 1649 Received:May 04, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.04.23 |
| Key Words
LoVo cell;Xihuang pills;medicine-contained serum;matrix metalloproteinase-2, 9 |
| Author Name | Affiliation | | SUN Li-na | Tianjin University of TCM, Tianjin 300193, China | | MENG Jing-yan | Tianjin University of TCM, Tianjin 300193, China | | WANG Wei | Tianjin University of TCM, Tianjin 300193, China | | YING Sen-lin | Tianjin University of TCM, Tianjin 300193, China | | LI Dan | Tianjin University of TCM, Tianjin 300193, China | | MA Zuo-ying | Tianjin University of TCM, Tianjin 300193, China | | JIA Yan-tao | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the effect of Xihuang pills(medicine-contained serum) on the protein expressions of matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9) in human colorectal carcinoma LoVo cell. [Methods] The enzyme-linked immunoassay (ELISA) was used to determine the expression of MMP-2 and MMP-9 in the culture solution of LoVo cell under the action of Xihuang pills. [Results] The expression of MMP-2 and MMP-9 in medication groups was significantly lower than those of control group (P < 0.05). [Conclusion] Xihuang pill has a potent effect of reducing the expressions of MMP-2 and MMP-9. This mechanism may play an important role in the suppression of colorectal carcinoma metastasis. |
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