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| Comparative experiment of TZQ on abnormal glucose and lipid metabolism in KK-Ay mice before and after passing macroporous resin |
| Hits 1565 Download times 1623 Received:March 10, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.04.25 |
| Key Words
Hawthorn Leaf;Danshen root;Red Paeony Root;macroporous resin;pharmacodynamics |
| Author Name | Affiliation | | LI Yu-hong | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China | | LIU Hong | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China | | WANG Qian | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China | | LI Jun-qing | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China | | ZENG Sen | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China | | ZHANG De-qin | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China | | HU Li-min | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China |
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| Abstract
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| [Objective] To compare the effects of Tangzhiqing(TZQ), a new traditional Chinese anti-diabetic prescription containing five ingredients, on abnormal glucose and lipid metabolism before and after passing macroporous resin in KK-Ay mice. [Methods] KK-Ay diabetic mice were administrated with TZQ before and after passing macroporous resin at the dose of 8, 4, 2 g/kg for 5 weeks. Glucobay was taken as control. The effect of TZQ on blood glucose and Lipid in mice before and after passing macroporous resin was observed. [Results] Both kinds of TZQ tended to reduce fresh water intaking, urine volume of KK-Aｙ mice. They could also significantly reduce the non-fasting glucose and glucose at 30, 60, 120 min after sucrose was given orally. They could decrease TG, serum insulin and improve the insulin resistance. [Conclusion] TZQ, made up by Hawthorn Leaf, Danshen root, Red Paeony Root and so on, does not decrease the pharmacologyic effect after processing by macroporous resin. |
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