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| Antiviral activity of Alternanthera Philoxeroides effective fractions extracts against virus A H3N2 |
| Hits 1498 Download times 1656 Received:June 21, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.05.22 |
| Key Words
Alternanthera philoxeroidis;MDCK cells;influenza A Virus H3N2;antiviral effect |
| Author Name | Affiliation | | LI Shuang | Hubei Key Laboratory of Resoure Science and Chemistry in Chinese Medicine, Hubei University of TCM, Wuhan 430061, China | | PENG Xiao-zhi | Hubei Key Laboratory of Resoure Science and Chemistry in Chinese Medicine, Hubei University of TCM, Wuhan 430061, China | | LIAO Peng-cheng | Hubei Key Laboratory of Resoure Science and Chemistry in Chinese Medicine, Hubei University of TCM, Wuhan 430061, China | | CHEN Shu-he | Hubei Key Laboratory of Resoure Science and Chemistry in Chinese Medicine, Hubei University of TCM, Wuhan 430061, China | | LIU Yan-wen | Hubei Key Laboratory of Resoure Science and Chemistry in Chinese Medicine, Hubei University of TCM, Wuhan 430061, China |
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| Abstract
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| [Objective] Using Alternanthera Philoxeroides effective fractions extracts as a research object, to further validate its biological activity in vitro anti-influenza A H3N2 influenza virus, in order to provide a basis for its development and application. [Methods] Ribavirin injection was used as a positive control drug. By observing the cytopathic effect (CPE) caused by the influenza A H3N2 influenza virus infection in MDCK cells, using MTT method to check the cell activity, and using therapeutic index (TI) as an evaluation of antiviral effect in vitro to evaluate the antiviral activity of the drugs. To evaluate the biological activity against influenza A H3N2 influenza virus of Alternanthera Philoxeroides effective fractions extracts. [Results] Alternanthera Philoxeroides effective fractions of extracts had significant antiviral biosynthesis of influenza virus. Its therapeutic index (TI) were (2.43±0.01). But its preventing the influenza virus adsorption and direct anti-influenza virus was not obvious. [Conclusion] Alternanthera Philoxeroides effective fractions extracts have certain anti-influenza virus, and its form is antiviral biosynthesis of influenza virus, and has a dose-dependent. |
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