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| Effect of Fuzheng mistura combined with chemotherapy on patients with non-small cell lung cancer in senile advanced stage |
| Hits 2132 Download times 2449 Received:August 21, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.06.06 |
| Key Words
Fuzheng mistura;non-small cell lung cancer;older patient;chemotherapy |
| Author Name | Affiliation | | ZHANG Ying | Department of Oncology, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | JIA Ying-jie | Department of Oncology, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | CHEN Jun | Department of Oncology, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | SUN Yi-yu | Department of Oncology, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | LI Xiao-jiang | Department of Oncology, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect and side reaction of Fuzheng mistura combined with GP scheme chemotherapy on patients with non-small cell lung cancer in senile advanced stage. [Methods] Fifty patients with confirmed diagnosis of advanced non-small cell lung cancer were enrolled. They were randomly divided into two groups. Group A was given with gemcitabine plus carboplatin solution chemotherapy intravenously, and group B with Fuzheng mistura orally. Twenty-eight days was a course and the treatment was continuously used for two chemotherapy courses. [Results] Fuzheng mistura in chemotherapy of older patients with advanced non small cell lung cancer had a therapeutic effect. In decreasing the cancer size the clinical benefit rate of group B was better than that of group A with significant difference (P<0.05). In reducing the serum tumor markers, the change of CEA level had significant difference (P<0.05) of both groups before and after treatment. There was no statistical difference in CYFRA-21 level (P>0.05). There was significant difference (P<0.05) between two groups of patients in the improvement of immune function, casparian score, clinical symptoms. A significant differences were also found in side reactions, nausea vomiting, decreasing of leucocyte count. Their incidence in group B was lower than that in group A. [Conclusion] Fuzheng mistura has effect-increasing and detoxification effect in chemotherapy in older patients with advanced non small cell lung cancer. |
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