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| Expression of collagen protein Ⅰ and Ⅲ in angiopathy of rats with diabetes and intervention with Chinese medicine |
| Hits 1725 Download times 1742 Received:August 08, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.06.18 |
| Key Words
type Ⅱ of diabetes mellitus;fibrosis of large vascular vessel;modified Taohe Chengqi decoction;collagen protein Ⅰ;collagen protein Ⅲ |
| Author Name | Affiliation | | DING Zhi-ming | Surgery Department, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | WU Hai-kuo | Surgery Department, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China | | WANG Jun | Surgery Department, The First Hospital Affiliated to Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the effect of Chinese medicine on the expression of collagen protein in rats with diabetes and arterial injury for providing the experimental evidences of theory of fiber neuropathy in arterial injury and to explore the intervention feasibility of Chinese medicine on diabetic vascular complications. [Methods] The 48 SD male rats were randomly divided into normal control group(A), diabetic control group (B), Chinese medicine treatment group (C), metformin treatment group (D), to observe the content of collagen protein Ⅰ,Ⅲ in the rats femoral artery. Diabetes was induced in B, C and D group. [Results] Compared with normal group, collagen Ⅰ and collagen Ⅲ were significantly increased in diabetes group; it was significantly decreased after treatment in each group compared with diabetic control group. Compared with Western medicine the expression of collagen Ⅰ, Ⅲ decreased in the Chinese medicine treatment group. [Conclusion] Collagen Ⅰ, Ⅲ increased markedly in vessels of middle, late period of diabetic rats, hinting that diabetic macroangiopathy may be associated with collagen protein; modified Taohe Chengqi decoction can effectively reduce the expression of fibrosis-inducing collagen protein in experimental diabetes induced macroangiopathy and has improvement effect on diabetic macrovascular diseases. |
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