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| Comparative study on absorption of mangiferin and its phosphate complex in intestine of rat |
| Hits 1707 Download times 1669 Received:November 11, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.06.22 |
| Key Words
mangiferin;phospholipid complex;intestinal absorption;rats in vivo single direction perfusion model |
| Author Name | Affiliation | | ZHANG Wei-ling | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | WANG Ya-jing | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | TIAN Hui | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | XUAN Xiao-yu | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | GAO Xu | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | YU Yue | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To compare the absorption of mangiferin and its phosphate complex in intestine of rats in vivo. The effect of phosphate complex on mangiferin. was investigated. [Methods] The rat single-direction intestinal perfusion model in vivo was used. HPLC method was applied to measure the concentrations of mangiferin and its phosphate complex in intestine perfusate of duodenum, jejunum, ileum and colon, taking mangiferin as the control. [Results] The absorption rate constant (Ka) and apparent absorption coefficient (Papp) of mangiferin phosphate complex in each intestinal segments were higher than that of mangiferin and had significant difference in jejunum (P<0.01). [Conclusion] The intestinal absorption of mangiferin phosphate complex is superior to that of mangiferin. |
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