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| Influence of Radix Ginseng and Radix Aconiti Lateralis Preparata in different proportion compatibility on acute toxicity in mice |
| Hits 1929 Download times 1591 Received:September 28, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2013.01.15 |
| Key Words
Radix Aconiti Lateralis Preparata;Radix Ginseng;attenuation with different compatibility;acute toxicity |
| Author Name | Affiliation | E-mail | | ZHOU Si-si | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
Graduated Department, Anhui Medical University, Hefei 230032, China | | | MA Zeng-chun | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | LIANG Qian-de | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | TANG Xiang-lin | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | WANG Yu-guang | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | TAN Hong-ling | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | XIAO Cheng-rong | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | ZHANG Bo-li | Tianjin University of TCM, Tianjin 300193, China | | | GAO Yue | Pharmacology and Toxicology Laboratory, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | gaoyue@bmi.ac.cn |
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| Abstract
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| [Objective] To investigation the effect of different compatibility of Radix Ginseng and Radix Aconiti Lateralis Preparata on toxicity in mice. [Methods] In this study two methods using uniform design and fixed dose of Radix Aconiti praeparata compatibility with Radix Ginseng were used to observe the influence of different proportion in compatibility of Radix Ginseng and Radix Aconiti Lateralis Preparata on acute toxicity in mice. [Results] The study of uniform design showed that mice mortality was increased with the dose increasing of Radix Aconiti Lateralis Preparata and with the proportion of Radix Ginseng increased the toxicitiy-decreasing effect had a increasing tendency. The research of the toxicity-attenuated role with the fixed LD50 dose of Radix Aconiti Praeparata and different proportion of Radix Ginseng showed that toxicity- decreasing effect in this compatibility of Radix Ginseng and Radix Aconiti Praeparata increased with the increasing dose of Radix Ginseng in a certain range, especially the dose of Radix Ginseng was more than or equal to the dose of Radix Aconiti Lateralis Preparata. [Conclusion] The cutoff point of the effect of attenuation was at a compatibility between Radix Ginseng and Radix Aconiti Lateralis Preparata in 1:1, which can provide some references in he usage of drugs in the clinical practice. |
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