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| Effect of Lingqi capsule on the expression of COX-2 in H22 tumor-bearing mice |
| Hits 2189 Download times 1359 Received:August 14, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2013.02.13 |
| Key Words
Lingqi capsule;Anti-tumor;H22;COX-2 |
| Author Name | Affiliation | E-mail | | LIU Xiao-dong | The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China
Heilongjiang University of TCM, Ha'erbin 150040, China | | | DAI Gui-jiang | The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China
Heilongjiang University of TCM, Ha'erbin 150040, China | | | LIU Bo | The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China
Heilongjiang University of TCM, Ha'erbin 150040, China | | | SU Yun-ming | The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China
Heilongjiang University of TCM, Ha'erbin 150040, China | suyunming@126.com |
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| Abstract
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| [Objective] To study the anti-tumor effect of Lingqi capsules (LQC) and further explore the mechanism of action. [Methods] The expression of angiogenic factor COX-2 was detected in tumor-bearing mice with immunohistochemical methods and to the LQC's inhibitory action to tumor angiogenesis was detected also. [Results] LQC could inhibit the tumor angiogenesis by down-regulating the expression of angiogenic factor COX-2. [Conclusion] LQC shows its anti-tumor effect by influencing the expression of angiogenesis-correlated factor and inhibiting the tumor angiogenesis. |
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