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| Prescription designing and content determination of Salvianolic acid B oral microemulsion |
| Hits 1782 Download times 1309 Received:November 25, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2013.02.16 |
| Key Words
Salvianolic acid B;W/O microemulsion;pseudo three dimensional diagram |
| Author Name | Affiliation | E-mail | | MA Li | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China | | | LIU Zhi-dong | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China | | | LI Nan | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China | linan20080402@163.com | | SUN Jing-tong | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China | | | ZHANG Qian | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China | | | YE Li-na | College of TCM, Tianjin University of TCM, Tianjin 300193, China | |
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| Abstract
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| [Objective] To identify the best prescription and the content determination method of the oral micro-emulsion of the hydrophilic Salvianolic acid B (Sal B) in type of water in oil (W/O). [Methods] A pseudo three dimensional phase diagram was prepared by Km value titration to investigate the influence of surfactant, cosurfactant, oil phase types, drug, Km value, temperature on the microemulsion area and select the best prescription combination of W/O microemulsion. Its content was determined by HPLC method. [Results] The microemulsion prescription with larger region was Labrafil M 1944CS/soybean lecithin (PC)/dehydrated alcohol/Sal B solution (45 mg/ml) (Km=1). The temperature for the preparation was (40±1)℃. [Conclusion] The optimal prescription can entrap Sal B in the aqueous phase, obtaining the homogeneous system of clear transparent and good fluidity. |
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