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Clinical effect of rhubarb combined with sodium sulfate on gastrointestinal dysfunction in critical care patients
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DOI   10.11656/j.issn.1672-1519.2013.03.07
Key Words   rhubarb;sodium sulfate;critical care patient;gastrointestinal function
Author NameAffiliation
SHEN Ling-hong Department of Intensive Care Unit, Zhuozhou City Hospital of Hebei Province, Zhuozhou 072750, China 
ZHENG Gui-jun Department of Intensive Care Unit, Zhuozhou City Hospital of Hebei Province, Zhuozhou 072750, China 
WANG Jun-mei Department of Intensive Care Unit, Zhuozhou City Hospital of Hebei Province, Zhuozhou 072750, China 
YUAN Ya-song Department of Intensive Care Unit, Zhuozhou City Hospital of Hebei Province, Zhuozhou 072750, China 
JIANG Jia-wei Department of Intensive Care Unit, Zhuozhou City Hospital of Hebei Province, Zhuozhou 072750, China 
Abstract
    [Objective] To observe the protective and treatment effects of rhubarb combined with sodium sulfate in critical care patients with gastrointestinal dysfunction. [Methods] The enrolled patients in the study had digestive disorders and APACHE Ⅱ≥16 scores and the patients with organic gastrointestinal diseases were excluded. In treatment group: the 50 mg of crude rhubarb was inserted in 100 mL of water at 100℃ for 15 minutes till dark brown was found. After that the drug was infused into the treatment patients by stomach tube feeding slowly, 3 times a day. At the same time 100 g of sodium sulfate in double dressing package was flatly masked on belly button, changed a time when the gauze bag became wet and changed 2~3 times a day. In control group: 10 mg of mosanpride tablets was given by nasal feeding, 3 times a day. The time of abdominal distension relieving, time of beginning to defecate, time of starting enteral nutrition and the incidence of gastrointestinal bleeding were observed in both groups. [Results] In treatment group the time of abdominal distension relieving, the time of smoothly starting enteral nutrition and defecate time were shorter than that in control group (P<0.05 or P<0.01). Incidence of gastrointestinal bleeding in treatment group was also significantly lower than that in control group. [Conclusion] Rhubarb combined with sodium sulfate can significantly protect the patients with gastrointestinal dysfunction in critical care, reduce the incidence of gastrointestinal bleeding and ameliorate the prognosis of patients.

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