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| Effects of four kinds of penetration enhancers on percutaneous absorption of Tetrahydropulmatine in Tongning gel in vitro |
| Hits 2873 Download times 1882 Received:December 30, 2012 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2013.03.18 |
| Key Words
penetration enhancer;Tongning gel;Tetrahydropulmatine;percutaneous absorption |
| Author Name | Affiliation | E-mail | | YIN Zhong-peng | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry f Education, Tianjin University of TCM Tianjin 300193, China | | | PANG Xiao-chen | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry f Education, Tianjin University of TCM Tianjin 300193, China | | | LIU Zhi-dong | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry f Education, Tianjin University of TCM Tianjin 300193, China | lonerliuzd@163.com | | ZHANG Qian | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry f Education, Tianjin University of TCM Tianjin 300193, China | | | XIAO Wei | Jiangsu Kanion Pharmaceut Co. Ltd., Lianyungang 222001, China
State Key Laboratory of New-tech for ChineseMedicine Pharmaceutical Process, Lianyungang 222001, China | |
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| Abstract
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| [Objective] To study the effects of Azone, Trans P, Lab and PG on percutaneous absorption of Tetrahydropulmatine across the skin of rats. [Methods] The Franzdiffusion chamber was applied for evaluating the effect of each penetration enhancer(PE) with different concentrations on the percutaneous absorption of tetrahydropulmatine in vitro. [Results] Compared with the control group, 0.5%Lab, 0.5%PG, 0.5%Azone, 3%Azone and 7% Trans P showed the permeability coefficient as much as 1.50, 1.52, 1.42, 1.46 and 1.66 folds respectively (P<0.01). Their penetration-increasing rates were 7% Trans P﹥0.5% PG﹥0.5%Lab﹥3%Aone﹥0.5%Azone in turn. [Conclusion] The enhancing effect of 0.5%Lab, 0.5%PG, 0.5%Azone, 3%Azone and 7%Trans P is significant and can be further used in the preparation of Tongning gel. |
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