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| Experimental study of Qixiong Jianshen granules in rats with IgA nephropathy |
| Hits 2622 Download times 1896 Received:January 15, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.04.16 |
| Key Words
IgA nephropathy;Qixiong Jianshen granule;Shenyan Kangfu tablet;Wistar rats;experimental study;immunofluorescence |
| Author Name | Affiliation | | ZHAO Ren | Department of Nephropathy, Tangshan Chinese Medicine Hospital, Tangshan 063000, China | | WU Di | Hebei United University, Tangshan 063000, China | | ZHU Xiao-fei | Hebei United University, Tangshan 063000, China | | MENG Fan-long | Hebei United University, Tangshan 063000, China |
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| Abstract
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| [Objective] To study the effects of Qixiong Jianshen granules in rats with experimental IgA nephropathy(IgAN). [Methods] The IgAN models were established in rats by oral administration and time-controlled injection of bovine serum albumin (BSA).The effect of Qixiong Jianshen granules on urinary red blood cell(RBC), 24-hour urine protein(Upr), serum creatinine(SCr), blood urine nitrogen(BUN) and the change of kidney pathology were studied. [Results] In Qixiong Jianshen granules of high-dose group (QHG) the kidney function were better than the model group with less urinary RBC, 24 h Upr, SCr, BUN(P<0.05), the proliferation of mesangial cells and the increasing of the mesangial matrix were inhibited and the deposit of IgA in the glomerular mesangial area was decreased. Among them, QHG was better than the Shenyan Kangfu tablet(the compared group) in decreasing 24 h Upr, SCr and improving the pathological injury of kidney. But there was no difference in decreasing urine RBC and BUN. [Conclusion] Qixiong Jianshen granules can effectively decrease IgAN hematuria, protein urine and improve the kidney function. It can also reduce the deposit of immunity complex in the glomerular mesangial area. So it is an effective prescription in the treatment of IgA nephropathy. |
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