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| Effect of different penetration enhancers on transdermal absorption of gallic acid in Jingwanhong compound recipe |
| Hits 2692 Download times 1902 Received:December 28, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2013.04.19 |
| Key Words
Jingwanhong;penetration enhancer;propylene glycol;Franz diffusion |
| Author Name | Affiliation | E-mail | | HUANG Qiu-xia | College of Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | | PAN Chao | College of Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | | GUO Da-liang | College of Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | | | LIU Wen-wei | Tianjin Darentang Jingwanhong Pharmaceutical Co. Ltd., Tianjin 300112, China | | | ZHAO Yu | Tianjin Darentang Jingwanhong Pharmaceutical Co. Ltd., Tianjin 300112, China | | | LIU Yu-xuan | College of Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China | lsrlyx2008@126.com |
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| Abstract
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| [Objective] To investigate and optimize the penetration enhancer in Jinwanghong compound recipe. [Methods] Franz diffusion of isolated abdominal skin of rats was used to investigate the penetration-promoted effect of propylene glycol, Azone, Labrasol and Transcutol respectively and optimize the excellent penetration enhancer and the dose. [Results] Selecting gallic acid as the index component, the accumulative permeation quantity per unit area of propylene glycol was surpassed the others with a steady state flow 0.721 μg/(mm2·h). The penetration-promoted ratio was 1.646 folds higher. The optimal dosage was 5%. [Conclusion] Analysis based on the effective constituents and matrix miscibility has found that propylene glycol is the optimal penetration enhancer. Since its higher viscosity, its used dosage should not be too large. |
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