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| Effect of Er Xian decoction on ovary function after injury of cisplatin in mice |
| Hits 2014 Download times 1619 Received:February 15, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.05.15 |
| Key Words
Er Xian decoction;reproduction hormone;ovary function |
| Author Name | Affiliation | E-mail | | AI Hao | Department of Obstetrics and gynecology, The Third Affiliated Hospital of Liaoning Medical College, Jinzhou 121000, China
Key Laboratory of Follicular Development and Reproduction Regulation of Liaoning Province, Jinzhou 121000, China | | | ZHANG Hai-ying | Liao ning Medical College, Jinzhou 121000, China | | | ZHANG Yu-li | Dongzhimen Hospital Affiliated to Beijing University of TCM, Beijing 100700, China | | | XUE Xiao-ou | Dongzhimen Hospital Affiliated to Beijing University of TCM, Beijing 100700, China | xxo123@sina.com |
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| Abstract
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| [Objective] To investigate the regulatory effect of Er Xian decoction on restoring ovary function in premature ovarian failure (POF) in mice injured by cisplatin (CDDP). [Methods] Female SD mice were given with cisplantin daily to set up the model of POF. The changes of genital hormones, ovulation, MDA, T-AOC and ovary morphology were observed in mice after intragastric administration of Er Xian decoction. [Results] Compared with model group, in the Er Xian decoction group FSH and LH decreased, E2 and P increased, MDA decreased and T-AOC increased in ovary tissue, less follicular atresia and intercellular substance presented, the fibrous degeneration of ovaries were ameliorated. [Conclusion] Er Xian decoction can restrain oxidative injury, reduce the formation of extracellular matrix and promote its degradation, thus can restore the function of follicle and granulocyte and improve ovary function. |
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