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| Study on effect of Ru An tablets on hyperplasia of mammary glands and hormone level in rats |
| Hits 1815 Download times 1456 Received:February 10, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.05.18 |
| Key Words
Ru An tablet;hyperplasia of mammary glands;estradiol;progesterone |
| Author Name | Affiliation | E-mail | | LIU Mao-jun | Traditional Chinese Medicine Hospital of Tianjin Heping District, Tianjin 200050, China | | | FENG Yue | Tianjin Research Center of Safety Evaluation of New Medicine, Tianjin 300301, China | | | SHEN Xiu-ping | Tianjin Research Center of Safety Evaluation of New Medicine, Tianjin 300301, China | | | HU Jin-fang | Tianjin Research Center of Safety Evaluation of New Medicine, Tianjin 300301, China | hujf@tjipr.com |
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| Abstract
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| [Objective] To study the effect of Ru An tablets on hyperplasia of mammary glands and hormone level in rats. [Methods] After hyperplasia of mammary glands was induced in rats, the rats were given Ru An tablets with lavage administration at high, middle, and low dose respectively for four weeks. The diameter and length of the nipple were measured and the size of the nipple was calculated. The contents of serum estradiol (E2), progesterone, prolactin (PRL) and testosterone were measured. The first and second pair of mammary glands were harvested, uterus and ovary were weighted to calculate the organ coefficients. The pthological examination of the mammary glands tissue was also conducted. [Results] All of the three doses of Ru An tablets could markedly decrease the diameter of nipple, length and size of the nipple of rats with proliferation of mammary glands, reduce markedly the weight of mammary glands and the coefficients of the mammary glands, and the coefficient of ovary and uterus, effectively decrease serum E2, PRL and E2/P level, increase the serum content of progesterone and testosterone and reduce the number of mammary gland flocculus, lobular gland bubble, mammary gland bubble and section in the cavity. [Conclusion] Ru An tablets has therapeutic effect on cyclomastopathy in rats by regulating sex hormone, improving morphology of hyperplasy mammary gland. |
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