|
| Effect of acupuncture on signs of senescence and cognitive function in SAMP8 mice |
| Hits 2086 Download times 4553 Received:March 11, 2013 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2013.06.12 |
| Key Words
Alzheimer’s disease;aging;cognitive function;“YiQi TiaoXue, FuBen PeiYuan” acupuncture |
| Author Name | Affiliation | E-mail | | WANG Li-yuan | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | | NIE Kun | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | | LIU Jin-feng | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | | LUO Ben-hua | The College of Zhuang Medicine, Guangxi University of TCM, Nanning, 530001, China | | | ZHANG Xue-zhu | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | zhangxuezhu1999@126.com |
|
| Abstract
|
| [Objective] To study the effect of acupuncture on delaying brain aging and the improvement of cognition. [Methods] The mice of SAMP8 and their corresponding normal control SAMR1 mice were assigned to the following four groups: SAMR1 control group (Rc), SAMP8 control group (Pc), SAMP8 acupuncture group (Pa) and SAMP8 non-acupoint group (Pn). Pa was treated with “YiQi TiaoXue, FuBen PeiYuan” acupuncture once daily for 15 days. For the Pn mice, the nonacupoints at hypochondrium on both sides of the body were stimulated. The two control groups were grasped in the same amount of time and with the same extent of strength as that in Pa and Pn. The degree of senescence in SAMP8 mice was evaluated by the grading score system. Spatial learning and memory of mice was assessed by using Morris water maze. [Results] Compared to the SAMR1, the grading scores were significantly higher in the SAMP8, exhibiting more severe impairments in hair loss, lack of hair glossiness, coarseness and reduced activities. The cognitive abilities of SAMP8 damaged apparently, which showed up by rigid thinking pattern and slow learning process in their Morris water maze tasks. After acupuncture treatment, the cognitive function of SAMP8 mice improved significantly, but the senescence scores for them were not changed. [Conclusion] Acupuncture can improve the cognitive dysfunction with aging may be a potential therapy and become a new treatment choice for Alzheimer's disease patients. |
|
|
|
|
|
|
|
