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| Study the effect of Xianji Huaban capsules on mast cell degranulation and histamine release |
| Hits 1996 Download times 1847 Received:February 11, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.06.13 |
| Key Words
Xianji Huaban capsules;PCA reaction;mast cell;degranulation;histamine |
| Author Name | Affiliation | E-mail | | GUO Hao | Heilongjiang University of TCM, Haerbin 150040, China | | | SU Yun-ming | Heilongjiang University of TCM, Haerbin 150040, China | | | ZHANG Ye | Heilongjiang University of TCM, Haerbin 150040, China | | | FANG Ming | Heilongjiang University of TCM, Haerbin 150040, China | | | SU Hui | Heilongjiang University of TCM, Haerbin 150040, China | suyunming@126.com |
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| Abstract
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| [Objective] To research the mechanism of Xianji Huaban capsules against hypersensitivity reaction, providing the foundation for later experiment and clinical treatment of allergic purpura. [Methods] By preparing the sensitization of rats and anti-egg protein in serum and giving different concentrations, we measured the skin blue spot diameter through the experimental of passive cutaneous anaphylaxis (PCA); then, we measured the degranulation percentage and the level of histamine release through the skull periosteum mast cells degranulation test and the mast cells release histamine test in rats. [Results] Xianji Huaban capsules could make the skin blue spot diameter smaller, decrease mast cells degranulation percentage, and reduce the release of histamine in a concentration dependent manner. [Conclusion] Xianji Huaban capsules have the effect against hypersensitivity reaction by inhibiting PCA, mast cells degranulation and histamine releasing. |
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