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| Research on correlation between blood gas changes and hepatic lesion in different stages of COPD in rats |
| Hits 1719 Download times 1395 Received:February 05, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.07.14 |
| Key Words
chronic obstructive pulmonary disease;arterial blood gas analysis;liver function;systemic correlation |
| Author Name | Affiliation | E-mail | | ZHANG Wei | The Affiliated Hospital of Shandong University of TCM, Jinan 250011, China | | | SUN Lu-lu | Shandong University of TCM, Jinan 250014, China | xingxingyu_2005@163.com | | HAN Jia | Shandong University of TCM, Jinan 250014, China | | | YAO Yu-qiang | Shandong University of TCM, Jinan 250014, China | | | GU Ming-ming | Shandong University of TCM, Jinan 250014, China | |
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| Abstract
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| [Objective] To exploit the modern study and application of the theory“COPD has correlation with multiple system”, this experiment based on “lung disease leading to liver disease”. It explored the correlation between the blood gas changes and the hepatic lesion in different stagings of the COPD from hypoxia aspect. [Methods] Rats were divided into three groups randomly with 8 rats in each group: the blank group (A), the COPD group (B), and the acute exacerbation of COPD group (C). The model of COPD was established by the improved passive smoking with LPS dropped into the trachea. Based on the model of COPD in first stage, the model of acute exacerbation of COPD was established by dropping LPS into the trachea again. Six hours later, the liver function was detected, the arterial blood gas was analyzed and the pathological changes of liver were observed under light and electron microscopy. [Results] Compared with the group A, the pH value and PaO2 of blood in the group B were decreased (P<0.05). These parameters was also decreased in group C (P<0.01). The arterial oxygen tension (PaO2) and oxygen saturation (SaO2) decreased significantly (P<0.01) in these two experimental groups, while the carbon dioxide partial pressure (PaCO2) obviously increased (P<0.01); compared with group B, the PH value of group C was decreased (P<0.01), PaO2 (P<0.01) and SaO2 ware decreased (P<0.01); PaCO2 was increased (P<0.01). Compared with group A, the content of ALT in group B was higher (P<0.05), TBIL was significantly increased (P<0.01), while ALB decreased (P<0.05). There was no significant difference in AKP. In group C, the contents of ALT, TBIL and AKP were all rose significantly (P<0.01); ALB was descend obviously. Compared with group B, the contents of ALT and AKP were higher (P<0.05); TBIL was significantly increased (P<0.01); ALB was decreased (P<0.05). Furthermore, the pH value and the PaO2 had negative correlation with the ALT and the TBIL, while the PaCO2 had positive correlation with the ALT and the TBIL significantly (P<0.01). The damage degree of the liver and lung tissue increased successively found under the light microscope and transmission electron microscopy in the group A, B and C. [Conclusion] With the exacerbation of hypoxia and the retention of carbon dioxide the hepatic function of the rats with COPD is further aggravated obviously. |
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