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| Effects of Qishengyiqi prescription on cardiomyocyte apoptosis and collagen volume fraction in rats with myocardial infarction |
| Hits 1857 Download times 1716 Received:April 23, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.08.16 |
| Key Words
Qishenyiqi extractum;myocardial infarction;apoptosis;collagen volume fraction |
| Author Name | Affiliation | E-mail | | LIU Yue | Tianjin People's Hospital, Tianjin 300121, China | | | QI Xin | Tianjin People's Hospital, Tianjin 300121, China | qinxinx@yahoo.com.cn | | LIU Ke-qiang | Tianjin People's Hospital, Tianjin 300121, China | |
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| Abstract
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| [Objective] To study the effects of Qishengyiqi prescription on cardiomyocyte apoptosis, myocardial infarction size and collagen volume fraction in rats with myocardial infarction (MI).[Methods] The rats with myocardial infarction were randomized into 3 groups: the groupA (sham operation with thorax opening without coronary artery deligation, n=10),the groupB (MI only, n=19), the groupC [n=14, treated with Qishenyiqi extractum, 100 mg/(kg·d)×28 after AMI, n=14].After treatment for 4 weeks,the infarct size, myocardial apoptosis index, mean density (MD) of Bcl-2, Bax protein and the collagen volume fraction were monitored.[Results] MD of Bcl-2 protein in the group B and C were more weaker than those of groupA (P<0.05),MD of Bax protein, the collagen volume fraction in the group B and C were stronger than those of group A.MD of Bcl-2 protein in the group C was stronger than those of the group B (P<0.05), the infarct size, MAI, MD of Bax protein and the collagen volume fraction were minor than those of the group B (P<0.05).[Conclusion] Qishenyiqi can relieve the left ventricular remodeling, improve the cardiac function and protect the heart in rats with myocardia infarction by inhibiting myocardium apoptosis and myocardial fibrosis.Key words |
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