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| Protective effect of baicalin against convulsion induced by pentylenetetrazol in mice |
| Hits 2547 Download times 2541 Received:March 20, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.08.17 |
| Key Words
baicalin;pentylenetetrazol;convulsion;latency to the first minimal clonic seizure;latency to the first generalized tonic-clonic
seizures |
| Author Name | Affiliation | | LIU Yang-feng | Neurology Department, No.451 Hospital of the PLA, Xi'an 710054, China | | CHI Li-yi | Neurology Department, No.451 Hospital of the PLA, Xi'an 710054, China | | GAO Fei | Neurology Department, The Second Affiliated Hospital
of Xi'an Jiaotong University, Xi'an 710004, China
| | MENG Xian-dong | Neurology Department, The Affiliated Xijing Hospital of The Fourth Military
Medical University, Xi'an 710032, China | | ZHANG Yan-hai | Neurology Department, No.451 Hospital of the PLA, Xi'an 710054, China | | JIANG Wen | Neurology Department, The Affiliated Xijing Hospital of The Fourth Military
Medical University, Xi'an 710032, China |
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| Abstract
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| [Objective] In this study we investigated whether baicalin could exert anticonvulsant effects in the pentylenetetrazol-induced convulsions in mice.[Methods] Mice were administered with PTZ subcutaneously at a dose of 100 mg/kg to induce convulsions.Baicalin were adiministrated 30 min prior to PTZ to evaluate its effects.[Results] The results were as followings: baicalin at the dose of 100 mg/kg delayed significantly the latency to first minimal clonic seizure, generalized tonic-clonic seizures and decreased the mortality as compared with control group.[Conclusion] These results indicate that the remarkable anticonvulsant effects of baicalin may be a potential supplement in the prevention and treatment of epilepsy and brain injury induced by epilepsy. |
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