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| Comparative study of anti-inflammatory effects between extracts of Isodonis Lophanthoidis var. graciliflora and Rabdosia serra |
| Hits 2421 Download times 2014 Received:March 28, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.08.18 |
| Key Words
Isodonis Lophanthoidis var. graciliflor;Rabdosia serra;anti-inflammatory |
| Author Name | Affiliation | E-mail | | KUANG Yan-hui | Institute of Chinese Medicine, Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, China | | | LIN Qing | Institute of Chinese Medicine, Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, China | linqinglore@sohu.com | | HUANG Lin | Institute of Chinese Medicine, Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, China | | | LI You | Institute of Chinese Medicine, Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, China | | | WANG De-qin | Institute of Chinese Medicine, Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, China | |
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| Abstract
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| [Objective] To study and compare the anti-inflammatory effects of extracts from Isodonis Lophanthoidis var.graciliflora and Rabdosia serra.[Methods] SPF Kunming mice were divided into model group,aspirin group(0.2 g/kg),Isodonis Lophanthoidis var.graciliflora water extract group (2.57,1.28,0.64 g/kg) group and Rabdosia serra extract (2.67,1.33,0.67 g/kg) groups.Each drug was administrated to mice orally once a day for 5 days.1 h after the last administration, the anti-inflammatory effects were observed by methods of xylene-induced auricular swelling and acetic acid-induced peritoneal inflammation, respectively.[Results] The water extract of Isodonis Lophanthoidis var.graciliflora could markedly decrease xylene-induced auricular swelling and inhibit acetic-acid induced increasing of permeability in peritoneal capillary in mice.But Rabdosia serra extract had no marked anti-inflammatory effects in decreasing the swelling of ear, and had less anti-inflammatory effects to decrease the increasing of the permeability of peritoneal capillary in less degree than Isodonis Lophanthoidis var.graciliflora extract.[Conclusion] The water extract of Isodonis Lophanthoidis var.graciliflora has stronger anti-inflammatory activities than Rabdosia serra extract does. |
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