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| Characterization and dissolution of resveratrol/hydroxypropyl-β-cyclodextrin inclusion complex |
| Hits 2999 Download times 1983 Received:April 16, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.08.19 |
| Key Words
resveratrol;hydroxypropyl-β-cyclodextrin;inclusion complex;solubility |
| Author Name | Affiliation | E-mail | | QI Xue-jie袁 | Chinese Medicine School of TCM, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of
Modern Chinese Medicine, Tianjin 300193, China
| | | QIU Chao | Tianjin State Key Laboratory of
Modern Chinese Medicine, Tianjin 300193, China
Research Center of TCM, Tianjin University of TCM, Tianjin 300193, China | | | JIANG Heng-li | Tianjin State Key Laboratory of
Modern Chinese Medicine, Tianjin 300193, China
Research Center of TCM, Tianjin University of TCM, Tianjin 300193, China | | | CUI Yuan-lu | Tianjin State Key Laboratory of
Modern Chinese Medicine, Tianjin 300193, China
Research Center of TCM, Tianjin University of TCM, Tianjin 300193, China | cuiyl@tjutcm.edu.cn |
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| Abstract
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| [Objective] Resveratrol hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex is prepared and characterized, stoichiometry of host and guest is determined and the dissolubility is also investigated.[Methods] The inclusion complex was prepared by freezedrying method, and characterized by Fourier-transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and X-ray
diffractometry (XRD).Drug content and release in vitro were determined by HPLC.[Results] It was defined that Resveratrol/HP-β-CD inclusion complex formed.Resveratrol/HP-β-CD was classified as AL-type with the ratio of 1:1 between host and guest, and the complexation constant was 1621M-1 by the phase solubility diagram method.Compared to the drug alone, solubility and dissolving rate of inclusion
complex increased.[Conclusion] The solubility, stability and dissolving rate of drug increases in inclusion complex of Resveratrol/HP-β-
CD. |
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