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| Study on stomach adhesion and sustained releasing microspheres containing total alkaloid from Zuojin pill |
| Hits 2047 Download times 1470 Received:April 25, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.09.17 |
| Key Words
Zuojin pill;total alkaloid from Zuojin pill;chitosan;stomach adhesion;microspheres |
| Author Name | Affiliation | E-mail | | GAO Teng | Research Center of Traditional Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | WANG Qiang-song | Research Center of Traditional Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | DONG Tian-jiao | Research Center of Traditional Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | CUI Yuan-lu | Research Center of Traditional Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | cuiyl@tjutcm.edu.cn |
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| Abstract
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| [Objective] To evaluate the technological feasibility of delivering total alkaloid from Zuojin pill using chitosan coated alginate/gelatin microspheres and determine the release behavior and bioadhesive properties. [Methods] The microspheres were prepared by an emulsification technique. Drug loading, encapsulation yield and release studies were also assessed by HPLC according to the Chinese pharmacopoeia. The bioadhesive property of microspheres was determined when it was adhered on the gastric mucosa of rat in vitro. [Results] The results of practical drug loading efficiency: hydrochloride jatrorrhizine was 2.768 mg/g, hydrochloride palmatine 3.986 mg/g, hydrochloride berberine 21.920 mg/g, evodiamine 1.449 mg/g, rutaecarpine 0.954 mg/g. The results of drug release behavior and bioadhesive properties studies on gastric mucoadhesive microspheres showed that the microspheres were continuously releasing drugs for 8 h and the stomach adhesion percentage was 89.33%. [Conclusion] The results imply that the microspheres are a useful dosage form to increase drug loading for the poorly water-soluble drugs by encapsulating with chitosan. It also indicated that they have satisfactory sustained releasing behavior in simulated gastric fluid. |
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