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| Effect of acupuncture on the expression of Nogo-A in rats with craniocerebral injury |
| Hits 1931 Download times 1437 Received:April 10, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.10.13 |
| Key Words
craniocerebral injury;Nogo-A;immunohistochemistry;acupuncture |
| Author Name | Affiliation | E-mail | | TIAN Gui-hua | Department of Massage, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100029, China | | | Wang Xi-you | Department of Massage, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100029, China | | | Yao Hai-jiang | School of acupuncture-moxibustion and tuina, Beijing University of Chinese Medicine, Beijing 100029, China | | | LI Zhi-gang | School of acupuncture-moxibustion and tuina, Beijing University of Chinese Medicine, Beijing 100029, China | lizhglq620@163.com |
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| Abstract
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| [Objective] To observe variation of Nogo-A expression after craniocerebral injury(CCI)of rats,and to investigate the protective mechanism of acupuncture in CCI. [Methods] Rats were randomly divided into three groups: acupuncture group, model group and blank control group. The craniocerebral injury rat model was made by using a modified Allen's method. The craniocerebral tissues on 6, 24, 48 h and 6 d after injury were taken. The expression of Nogo-A was detected through immunohistochemistry mothods. The positive cells were analyzed by a computer image analysis system. [Results] After CCI rat model was established successfully,and the Nogo-A content of local injury tissues in acupuncture group began to decline from 24 h. Compared with the model group,statistical significance was found in the acupuncture group at 48 h, 6 d(P<0.01).[Conclusion] The acupuncture can obviously inhibit the expression of Nogo-A of the CCI rat and it is likely to play a role in the axon regeneration along the correct direction after CCI. |
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