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| Influence of penetration enhancer on transdermal permeation of Tongning gel in vivo |
| Hits 2223 Download times 1471 Received:May 06, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2013.10.14 |
| Key Words
microdialysis;Tongning gel;penetration enhancer;transdermal delivery;tetrahydropalmatine |
| Author Name | Affiliation | | LIU Zhi-dong | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | YIN Zhong-peng | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | PANG Xiao-chen | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | ZHANG Qian | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of TCM, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | XIAO Wei | Jiangsu Kanion Pharmaceut Co. Ltd., Lianyungang 222001, China
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China |
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| Abstract
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| [Objective] To study the transdermal absorption of Tongning gel in rats with or without the widely used enhancer 7% Transcutol P and 0.5% Labrosal. [Methods] Using in vivo transcutaneous sampling technique with micro-dialysis and taking SD rats as the model the experiment was performed. The recovery rate in vivo was assessed with retrograde microdialysis probe.[Results] The in vivo recovery of the control, the 7%Transcutol P and the 0.5% Labrosal was 57.8%±5.09%, 53.02%±1.25% and 46.57%±0.49% respectively. The steady state flux of Tetrahydropalmatine in dialysate(Js) was 1.06, 11.38 and 2.28 ng/h respectively. The lag time was-0.32, 0.75 and 0.25 h. [Conclusion] The concentrations of tetrahydropalmatine in the dialysate and the dermis are increased greatly by 7% Transcutol P. So this preparation is suitable for transdermal drug delivery, and is likely to apply in the preparation of the Tongning gel. |
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