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| Effect of acupuncture in regulating mitochondria permeability transition pore opening in Alzheimer disease mice with mitochondrial dysfunction |
| Hits 1623 Download times 1337 Received:July 10, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2014.01.08 |
| Key Words
Aβ42;CypD;AD;mPTP;mitochondrion |
| Author Name | Affiliation | | FU Yu | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | XING Jing | The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150009, China | | GUO Rui-jing | Tianjin University of TCM, Tianjin 300193, China | | LIU Yu-jing | Tianjin University of TCM, Tianjin 300193, China | | HAO Ting-ting | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the effect of "SanJiao" acupuncture in regulating the associated protein CypD and Aβ about mitochondria permeability transition pore opening in Alzheimer disease mice. [Methods] Using SAMP8 mouse and normal control SAMR1 as model, applying the Western blot techniques, monitoring the expression difference of CypD and Aβ in procerebrum,neocortex and hippocampus and the effect of acupuncture. [Results] The expression of Aβ42 and CypD in cortex and hippocampus decline in SAMR1, obviously increased in SAMP8, downregulated or had the tendency of downregulation after acupuncture. [Conclusion] The result confirms that "SanJiao" acupuncture treatment can regulate the expression of Aβ42 and CypD in cortex and hippocampus in SAMP8 rats. |
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