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| Analysis of seven active component alignment corresponding to function of Rhubarb |
| Hits 1901 Download times 1349 Received:June 18, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2014.01.14 |
| Key Words
the function of Rhubarb;active component aligment;correlation;variation rule |
| Author Name | Affiliation | E-mail | | LIU Jing-jing | The Institute of Chinese Materia Medica, Beijing University of TCM, Beijing 100102, China | | | ZHANG Gui-jun | The Institute of Chinese Materia Medica, Beijing University of TCM, Beijing 100102, China | guijunzhang@163.com | | PENG Hui | The Institute of Chinese Materia Medica, Beijing University of TCM, Beijing 100102, China | | | ZHANG Ya-nan | The Institute of Chinese Materia Medica, Beijing University of TCM, Beijing 100102, China | | | ZHANG Zhi-yuan | The Institute of Chinese Materia Medica, Beijing University of TCM, Beijing 100102, China | |
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| Abstract
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| [Objective] To analyze of the variation rule of the seven active component alignment (ACA) corresponding to the basic functions of Rhubarb, including clearing away heat and toxic material, purging fire and detoxification, eliminating stagnant and treating jaundice and study the correlation of compatibility of medicines, formulation and active components alignments and provide scientific data for resolving the essence of traditional Chinese medicine. [Methods] Prepared the samples of Rhubarb and its prescriptions based on the classic Chinese medicine preparation method, the content of seven ACA of Rhubarb were determined by reversed phase high-performance liquid chromatography (RP-HPLC). [Results] The ACA corresponding to the basic functions of Rhubarb were aloe-emodin, rhein, emodin, chrysophanol, physcion, sennoside A, sennoside B. The content of those ACA was （0.140±0.02）, （0.250±0.013）, （1.100±0.027）, （0.170±0.006）, （0.050±0.002）, （0.747±0.033）, （1.085±0.023）mg/g respectively. [Conclusion] The ACA of Rhubarb are aloe-emodin, rhein,emodin, chrysophanol, physcion, sennoside A, sennoside B. The ACA proportion of clearing away heat and toxic material are 2.73:3.23:8.85:3.19:1:4.5:12.41;The ACA proportion of purging fire of detoxification are 2.67:3.97:15.52:3.28:1:20.89:10.51;The ACA proportion of eliminating stagnant are 1.69:6.37:10.65:2.23:1:7.11:5.98;The ACA proportion of treating jaundice are 1.71:2.39:8.04:2.30:1:5.43:78.99. There are significant differences between all the functions(P<0.01). The active components alignments are correlating with the compatibility of medicines and formulation. The functionality substance of Rhubarb is the active component alignment. |
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