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| The study of therapeutic effect and mechanism of Puerariae Radix polysaccharides on type 2 diabetes mellitus rats |
| Hits 1800 Download times 2007 Received:November 27, 2013 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2014.02.09 |
| Key Words
Puerariae Radix polysaccharides;type 2 diabetes mellitus;antioxidant |
| Author Name | Affiliation | E-mail | | CAI Chun-chen | Department of Endocrinology, The Fifth Central Hospital of Tianjin, Tianjin 300450, China | | | XU Yan-ying | Tianjin University of TCM, Tianjin 300193, China | | | WANG Hong-xi | Department of Endocrinology, The Fifth Central Hospital of Tianjin, Tianjin 300450, China | | | WANG Su | Department of Endocrinology, The Fifth Central Hospital of Tianjin, Tianjin 300450, China | 115122328988@126.com |
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| Abstract
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| [Objective] To study the therapeutic effect and mechanism of Puerariae Radix Polysaccharides (PRP) on type 2 diabetes mellitus (T2DM) rats. [Methods] Diabetic rats induced by high-fat diet with STZ were administered PRP and effects of PRP on body weight, FBG, OGTT, FINS, TG and TC were investigated. Then, the antioxidant effects of PRP were evaluated by detection the levels of SOD, CAT and MDA. [Results] PRP could increase the body weight, and reduce the content of FBG, and enhance FINS level and improve the oral glucose tolerance ability. Meanwhile, TG and TC of diabetic rats were also decreased after PRP treatment. Furthermore, PRP showed an obvious antioxidant effect through increasing SOD, CAT activities and decreasing MDA content in livers. [Conclusion] These results indicated obvious hpyerglycemic and hypolipidemic effects of PRP on diabetic rats and antioxidant effects might be a possible reason for these effects. |
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