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| Studies on release characteristics of different preparation of glipizide and intrinsic and exoteric correlation based on Single cell drug dissolution/absorption simulating system |
| Hits 2013 Download times 1691 Received:August 23, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2014.02.11 |
| Key Words
Single cell drug dissolution/absorption simulating system;glipizide;in vitro/in vivo correlation |
| Author Name | Affiliation | E-mail | | XUN Ming-jin | Faculty of Chinese Materia Medica, Tianjin University of TCM, Tianjin 300193, China | | | Yaro Peter | Faculty of Chinese Materia Medica, Tianjin University of TCM, Tianjin 300193, China | | | GU Sheng-pan | Faculty of Chinese Materia Medica, Tianjin University of TCM, Tianjin 300193, China | | | HE Xin | Faculty of Chinese Materia Medica, Tianjin University of TCM, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | hexintn@163.com |
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| Abstract
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| [Objective] To study the drug release characteristics in Single cell drug dissolution/absorption simulating system (Single cell-DDASS) and the correlation between the dissolution in vitro and the absorption in vivo of glipizide immediate release tablet and glipizide sustained release tablet. [Methods] The release characteristics of glipizide different preparation were investigated using dissolution testing described in Pharmacopoeia of the People's Republic of China (CHP) and Single cell-DDASS. Single-dose pharmacokinetic studies for the tablets were carried out in six beagle dogs. The percent in vivo absorption in beagle dogs was calculated by Wagner-Nelson method. The correlations between release characteristics in both CHP method and Single cell-DDASS and in vivo absorption were investigated. [Results] The release pattern of glipizide sustained release tablet in vitro could be described by zero-order kinetics and release mechanism was attributed to the dissolution mechanism. Glipizide immediate release tablet dissolution was fast in CHP method and in vitro/in vivo correlation could not be established. The correlation, however, between glipizide immediate release tablet release characteristics in Single cell-DDASS and the absorption in beagle dogs was significant (r=0.773 2, P<0.05). The correlation between release characteristics of glipizide sustained release tablet in CHP method and the absorption in beagle dogs was significant (r=0.811 5, P<0.05); the correlation between release characteristics of glipizide sustained release tablet in Single cell-DDASS method and the absorption in beagle dogs was also significant (r=0.987 7, P<0.01). [Conclusion] There is a significant correlation between Single cell-DDASS release and absorption of beagle dogs for glipizide immediate release tablet and glipizide sustained release tablets, and the correlation degree is higher than that between dissolution test described in CHP method and absorption in beagle dogs. Single cell-DDASS can be used to evaluate the in vivo absorption of glipizide immediate release tablet and sustained release tablet. |
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