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| Multi-center clinical trial of Shegan Liyan oral liquid in treating acute infantile pharyngitis with intenseness of heat in lung and stomach |
| Hits 2388 Download times 2057 Received:December 14, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2014.03.04 |
| Key Words
Shegan Liyan oral liquid;acute infantile pharyngitis;syndrome due to excess heat in the lung and stomach;clinical trial |
| Author Name | Affiliation | E-mail | | XU Tian-hua | The Post-graduated Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Xin-min | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Ya-feng | The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110034, China | | | WANG Ming-yue | The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China | | | CHEN Ding-ding | Traditional Chinese Medicine Hospital in Jingzhou city, Jingzhou 434000, China | | | ZHANG Guang-fang | Traditional Chinese Medicine Hospital in Langfang city, Langfang 065000, China | | | LIU Xia | Affiliated Hospital of Chengde Medical University, Chengde 067000, China | | | HU Si-yuan | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | husiyuan1963@sina.com |
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| Abstract
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| [Objective] To observe the efficacy and safety of Shegan Liyan oral liquid n treating acute infantile pharungitis with intenseness of heat in lung and stomach. [Methods] A method with randomized, positive-drug, parallel-controlled, doubled-blind, double-dummy, multi-center trial was designed in the clinical study. The 360 cases were served as treatment group, taking oral Shegan Liyan liquid for 4 days. 120 cases as control group, receiving Yanbian granules for 4 days. The curative effectiveness in syndrome of TCM was the main observing paramete. [Results] The total effective rate of treatment group was 83.72% and that of the control group was 71.05%. The syndrome total effective rate of treatment group was 84.30% and that of control group was 70.17% with significant difference between two groups(P=0.00).The single symptom effective rate in the treatment group was superior than that in the control group (P<0.05). One case with adverse event of stomach bursting pain was found in treatment group. No abnormal changes of laboratory indexes with clinical significance were observed in both groups. [Conclusion] Shegan Liyan oral liquid is safe and effective in treating acute infantile pharyngitis with syndrome due to excess heat in the lung and stomach. |
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