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| Mechanism of Songling Xuemaikang capsule on renal lypertension in rats with liver Yang hyperactivity |
| Hits 2308 Download times 3084 Received:July 02, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2014.03.12 |
| Key Words
Songling Xuemaikang capsule;hyperactivity of liver Yang hypertension;RAAS;ET-NO |
| Author Name | Affiliation | | LI Jie | The Second Department of Cardiology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | ZHAO Ying-qiang | The Second Department of Cardiology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | LIU Wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To research the blood pressure regulating mechanism of Songling Xuemaikang capsule in treating renal hypertension in rats with hyperactivity of liver yang. [Methods] Hypertension in the model group of rats with hyperactivity of liver yang was reproduced by ligaturing the left renal artery and oral infusion with monkshood soup. The 24 SD rats with successful reproduction of hypertension were randomly divided into 3 groups, including model group, Chinese medicine group and Western medicine group. The other 8 normal SD rats were served as blank group. Songling Xuemaikang capsule was given to the rats of Chinese medicine group and Ramipril was given to Western medicine group, while the same volume of saline was fed to the animals in blank group and model group for 4 weeks. The appearance of signs and degree of rats' irritability were observed. The pain threshold, blood pressure, ultrasonic cardiogram, AngⅡand ALD were measured. The expression of AT1R, ACE, eNOS and ET mRNA in tissue were measured. [Results] In the model group these hypertensive rats with hyperactivity of liver yang were reproduced successfully. The Songling Xuemaikang capsule could also improve the irritability symptoms of rats. The increased blood pressure could be inhibited and declined gradually, and the AT1R, ACE, ET mRNA expression were decreased, but the eNOS mRNA was increased after 4 weeks' treatment of Songling Xuemaikang capsule. At the same time, the indicators about LVDd, LVDs, LVPWd and LVPWs were lower. EF was increased significantly. [Conclusion] Songling Xuemaikang capsule can improve the symptoms about hyperactivity of liver yang, reduce the blood pressure by affecting the systems RAAS and ET-NO. In the end the ventricular remodeling is inhibited and the cardiac function is improved. |
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