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| Preparation and character in pharmacy of Scutellarein loaded PLGA nanoparticles |
| Hits 1900 Download times 1761 Received:July 07, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2014.03.15 |
| Key Words
Scutellarein;PLGA;nanoparticle;emulsion solvent evaporation |
| Author Name | Affiliation | E-mail | | LI Nan | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Li-li | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhi-dong | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com | | WANG Ai-chao | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Li-li | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHOU Mo | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To optimize the processing parameters of Scutellarein loaded PLGA nanoparticles(PLGANP) and study the character in pharmacy of the optimal Scutellarein-PLGANP. [Methods] Seven processing parameters were assessed systematically to enhance the Scutellarein incorporation into PLGA nanoparticles and to minimize the particle size,including PVA concentration in the aqueous phase, PLGA models, PLGA molecular mass, PLGA concentration in the organic phase, aqueous phase/organic phase volume ratio, acetone/ethanol volume ratio, Scutellarein/ PLGA mass ratio. [Results] The Scutellarein-PLGANP produced by the optimal formulation were submicron size of (126.80±4.50) nm and the zeta potential was (-21.30±0.23) mV,with the entrapment efficiency of (95.03±1.33)%. [Conclusion] Scutellarein drug loaded PLGANP can be prepared by O/W emulsion solvent evaporation. |
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