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| Protective effect of SMB against pulmonary arterial hypertension caused by MCT in rats |
| Hits 1670 Download times 1497 Received:October 24, 2013 |
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| DOI
10.11656/j.issn.1672-1519.2014.04.13 |
| Key Words
salvia miltiorrhiza bunge;monocrotaline;pulmonary arterial hypertension |
| Author Name | Affiliation | | WANG Zhi-hua | Department of Paediatrics, Tianjin Nankai Hospital, Tianjin 300100, China | | WANG Yu-shui | Department of Paediatrics, Tianjin Nankai Hospital, Tianjin 300100, China |
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| Abstract
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| [Objective] To investigate the protective effects of SMB in rats with pulmonary arterial hypertension caused by MCT. [Methods] Thirty male rats were randomly divided into three groups:normal control group, PAH group, SMB group. The rats in PAH group and SMB group were injected with a single subcutaneous MCT(50 mg/kg)respectively to induce the models of vascular remodeling of pulmonary artery． The rats in these 3 groups were fed in the same condition. After 3 weeks, SMB group was injected with SMB[200 mg/(kg·d)] intraperitoneally. Nothing was given in normal control group. The microstructure changes of small arterial were determined and observed two weeks later． [Results] MT,MT%,MA% and VA% of pulmonary arterial in SMB group were compared with those of pulmonary arterial in PAH group and control group respectively,and there was a statistical difference (P<0.05). [Conclusion] To some degree, SMB can reverse the progression of the pulmonary arteries remodeling, decrease effectively PAH, then repair the monocrotaline damaged lung． |
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