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| Effect of resolving toxin and dissolving stasis method in prevention of contrast-induced nephropathy in elderly patients with stable angina pectoris |
| Hits 1680 Download times 1377 Received:January 02, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.06.04 |
| Key Words
resolving toxin and dissolving stasis method|stable angina pectoris|contrast-induced nephropathy|percutaneous coronary intervention|elderly |
| Author Name | Affiliation | | ZHANG Ping | Tianjin Nankai Hospital, Tianjin 300100, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | ZHANG Guang-jin | Tianjin Xiqing District Hospital of Traditional Chinese Medicine, Tianjin 300380, China | | WANG Dong-qiang | The First Central Hospital of Tianjin, Tianjin 300192, China | | ZHANG Hong | Tianjin Nankai Hospital, Tianjin 300100, China | | LIU Jie | Tianjin Nankai Hospital, Tianjin 300100, China |
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| Abstract
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| [Objective] To investigate the effects of resolving toxin and dissolving stasis method in prevention of contrast-induced nephropathy (CIN) in elderly patients with stable angina pectoris. [Methods] The 184 elderly patients with stable angina pectoris were randomized into two groups, 90 in the control group and 94 in the treated group. On the base of conventional Western medicinal therapy, the treated group was given resolving toxin and dissolving stasis method from preoperative 3 d to postoperative 3 d in angioplasty. The values of serum creatinine (Scr) was detected before angioplasty and for continuous 3 d after angioplasty. Then the values of urine Cys-c, IL-18 and KIM-1 were measured and compared 24 hours and 48 hours after contrast administration. The incidence rates of CIN were compared between two groups. [Results] The levels of Scr, urine Cys-c, IL-18 and KIM-1 were lower in the treated group than those in the control group after contrast administration (p<0.01). CIN occurred in 19 cases (10.33%). There were 4 cases(4.26%)of CIN in the treated group as compared to 15 cases (16.67%) in the control group,which had significant difference (p<0.05). [Conclusion] Resolving toxin and dissolving stasis method can effectively prevent CIN in elderly patients with stable angina pectoris underwent the percutaneous coronary intervention. |
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