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| Clinical observation of treating zoster with nerve block combined with breviscapine |
| Hits 1923 Download times 1491 Received:February 05, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.06.09 |
| Key Words
breviscapine|zoster|neuralgia |
| Author Name | Affiliation | | JI Wen-xin | Department of Anesthesiology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | LI Zhong-lian | Department of Anesthesiology, The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the curative effects of breviscapine on the zoster. [Methods] The ents with zoster were divided into observation group and control group at random, then the control group was treated with oral drugs (famciclovir 0.25 g, 3 times a day; mecobalamin 0.5 mg, 2 times a day; gaba martin 300 mg) and nerve block (neurotropin in 3.6 IU, Vitamin B12 0.5 mg, 4%lidocaine diluted to 20 mL with sodium chloride). The observation group was treated with 50 mg of breviscapine injection and NS 250 mL through intravenous drip for 14 days. [Results] The VAS of each group decreased obviusly after treatment for 7 days compared with the VAS before treatment, the difference between two groups was significant (p<0.05). Scab time was (6.8±3.9), (4.6±2.8) days. Decrustation time was (14.1±4.7), (8.9±3.1) days, and observation group was significantly lower than the control group. The difference was statistically significant (p<0.05). After 30 d treatment, the total effective rate between two groups was 100%, and the excellence rate of observation group and control group was 85.7%and 82.8%. After 6 months followed to the patients with lesions after recovery, postherpetic neuralgia occurrence rate of observation group and control group was 8.6% and 14.3%. During the period of treatment, the two groups of patients had no adverse reaction. [Conclusion] Breviscapine injection is a kind of effective drugin treating patients of zoster. It can improve the nerve fibers of the microcirculation, promote nerve repair, reduce the intensity of pain patients, and improve the symptom of zoster, effectively prevent and reduce postherpetic neuralgia. |
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