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| Observation of the clinical efficacy on the prevention of the mannitol renal damage in patients treated with different concentrations of herbal retention enema |
| Hits 1803 Download times 2156 Received:April 17, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.07.04 |
| Key Words
eliminating the turbid by purgation method;herbal enema;stroke;mannitol;acute kidney injury |
| Author Name | Affiliation | | ZHANG Yan-shuang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | BAI Hui-mei | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | SUN Xi-gang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | SONG Yi | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the clinical efficacy on the stroke patients with acute renal damage caused by the mannitol treated by different concentrations of herbal retention enema. [Methods] The 30 patients were recruited and randomly divided into the test group and the control group, 15 cases in each group. Two groups of patients with increased intracranial pressure caused by the mannitol as the main dehydrating agent. The same dose of retention enema herb was used for 30 min, 1 time every day. Patients in test group were treated with 50 mL concentrated liquid retention enema, while the control group with 200 mL common concentration liquid retention enema. The efficacy of serum creatinine, blood urea nitrogen, serum cystatin C and comfort acceptance of patients were detected to assess the efficacy of patients between two groups before treatment, 5 days and 10 days after treatment. [Results] One case of damage occurs in treatment group with mannitol renal damage. The incidence was 6.67%. Mannitol renal damage occurred twice including one died due to cerebral edema in control group. The incidence was 13.33%. Both group were no statistically significant difference (P>0.05). The renal function indexes of patients between two groups in the process were similar (P>0.05). Comparison of comfort level of receiving enema of patients between two groups, the test group was better (P<0.05). [Conclusion] Eliminating the turbid by purgation method retention enema can effectively prevent the acute kidney damage caused by intravenous mannitol. The use of high concentration, less amount of fluid herbal retention enema is effective. In addition, patients' acceptability, compliance and comfort are on a higher degree. All above are worthy of further exploration. |
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